Stefanos Tsitsipas became the first Greek to reach the Roland Garros fourth round on multiple occasions on Saturday.
The fifth seed was leading 6-1, 6-2, 3-1 when Aljaz Bedene, who received on-court treatment for a right foot injury, retired after 80 minutes on Court Suzanne-Lenglen.
Tsitsipas, who is now 25-9 on the 2020 season, will next face Bulgarian No. 18 seed Grigor Dimitrov for the first time.
The 22-year-old lost just 12 of his service points, hitting 10 aces among 28 winners prior to Bedene retiring from their second ATP Head2Head meeting. The 31-year-old Slovenian had beaten Tsitsipas 7-5, 6-4 at the ABN AMRO World Tennis Tournament in Rotterdam in February.
Dimitrov also advanced courtesy of a retirement. The 18th seed was leading Roberto Carballes Baena 6-1, 6-3 when the Spaniard touched racquets to bring the 64-minute encounter to a close.